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Masataka Okuno Selected Research

3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acid

1/2011Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells.
3/2007Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells.
1/2005Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. Updated analysis of the long-term follow-up data.
5/2004Retinoids in cancer chemoprevention.
4/2004Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review).
8/2003Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.
11/2002Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells.
5/2002Acyclic retinoid induces partial differentiation, down-regulates telomerase reverse transcriptase mRNA expression and telomerase activity, and induces apoptosis in human hepatoma-derived cell lines.
1/2002Retinoids in liver fibrosis and cancer.

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Masataka Okuno Research Topics

Disease

15Hepatocellular Carcinoma (Hepatoma)
01/2011 - 01/2002
12Neoplasms (Cancer)
12/2017 - 01/2002
5Carcinogenesis
10/2007 - 09/2002
3Adenoma (Adenomas)
10/2007 - 09/2002
2Cholangitis
11/2021 - 02/2016
2Pathologic Constriction (Stenosis)
11/2021 - 09/2019
2Neoplasm Metastasis (Metastasis)
12/2017 - 02/2016
2Liver Diseases (Liver Disease)
09/2007 - 08/2003
2Leukemia
09/2007 - 05/2004
2Liver Cirrhosis (Hepatic Cirrhosis)
09/2007 - 01/2002
2Carcinoma (Carcinomatosis)
09/2007 - 06/2004
1Rectal Neoplasms (Rectal Cancer)
12/2021
1Pancreatic Neoplasms (Pancreatic Cancer)
05/2021
1False Aneurysm (Pseudoaneurysm)
02/2020
1Neuroendocrine Tumors (Neuroendocrine Tumor)
02/2020
1Hemorrhage
02/2020
1Cysts
12/2019
1Jaundice (Icterus)
11/2019
1Alkalosis
11/2019
1Rectovaginal Fistula
09/2019
1Foreign Bodies (Foreign Body)
09/2019
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
08/2019
1Necrosis
08/2019
1Obesity
01/2019
1Overweight
01/2019
1Stomach Neoplasms (Stomach Cancer)
01/2019
1Pericardial Effusion
12/2017
1Breast Neoplasms (Breast Cancer)
12/2017
1Lymphatic Metastasis
02/2016
1Healthcare-Associated Pneumonia
11/2013
1Hyperamylasemia
03/2008
1Colonic Neoplasms (Colon Cancer)
11/2007
1Colorectal Neoplasms (Colorectal Cancer)
11/2007
1Wounds and Injuries (Trauma)
09/2007
1Head and Neck Neoplasms (Head and Neck Cancer)
09/2007
1Chronic Hepatitis (Chronic Active Hepatitis)
09/2007
1Uterine Cervical Neoplasms (Cancer of the Cervix)
09/2007
1Liver Neoplasms (Liver Cancer)
09/2007
1Fistula
09/2007
1Endotoxemia
03/2005
1Non-Hodgkin Lymphoma (Lymphosarcoma)
02/2005

Drug/Important Bio-Agent (IBA)

93,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA
01/2011 - 01/2002
7RetinoidsIBA
10/2007 - 01/2002
4Retinoid X Receptors (Retinoid X Receptor)IBA
12/2007 - 02/2002
4Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
12/2007 - 01/2002
4Proteins (Proteins, Gene)FDA Link
11/2007 - 09/2002
4LigandsIBA
11/2007 - 02/2002
4Retinoid X Receptor alphaIBA
10/2007 - 01/2002
4Vitamin A (Retinol)FDA LinkGeneric
01/2005 - 01/2002
3InterferonsIBA
09/2007 - 05/2004
2Antineoplastic Agents (Antineoplastics)IBA
11/2007 - 05/2004
2beta CateninIBA
10/2007 - 09/2002
2(2E,4E,6E,10E)- 3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA
01/2005 - 06/2004
2Transforming Growth Factor alpha (TGF-alpha)IBA
01/2005 - 06/2004
2LectinsIBA
04/2004 - 01/2002
2alpha-Fetoproteins (alpha-Fetoprotein)IBA
04/2004 - 01/2002
1CA-19-9 Antigen (CA 19-9 Antigen)IBA
12/2019
1CarbohydratesIBA
12/2019
1Carcinoembryonic AntigenIBA
12/2019
1Tumor Biomarkers (Tumor Markers)IBA
12/2019
1Bile Acids and Salts (Bile Acids)IBA
11/2019
1Diethylnitrosamine (N-Nitrosodiethylamine)IBA
01/2011
1Caspase 3 (Caspase-3)IBA
01/2011
1ErbB Receptors (EGF Receptor)IBA
01/2011
1TransglutaminasesIBA
01/2011
1Sp1 Transcription FactorIBA
01/2011
1Hypnotics and Sedatives (Sedatives)IBA
03/2008
1Pharmaceutical PreparationsIBA
03/2008
1retinoic acid receptor betaIBA
12/2007
1AgarIBA
12/2007
1ciglitazoneIBA
11/2007
1AlitretinoinFDA Link
11/2007
1PPAR gammaIBA
11/2007
1Glutathione Transferase (Glutathione S-Transferase)IBA
10/2007
1MethyldimethylaminoazobenzeneIBA
10/2007
1Vitamin KFDA Link
09/2007
1Antiviral Agents (Antivirals)IBA
09/2007
1Vitamin K 2 (Vitamin K2)IBA
03/2007
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
03/2007
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2005
1Interleukin-2 Receptors (IL 2 Receptor)IBA
02/2005

Therapy/Procedure

5Chemoprevention
11/2007 - 01/2002
4Therapeutics
11/2013 - 01/2002
3Drug Therapy (Chemotherapy)
12/2017 - 01/2002
2Pelvic Exenteration
12/2021 - 08/2019
2Urinary Diversion (Ileal Conduit)
12/2021 - 08/2019
2Gastrectomy
02/2020 - 01/2019
2Aftercare (After-Treatment)
12/2017 - 09/2002
1Sutures (Suture)
11/2021
1Pancreaticoduodenectomy
11/2021
1Pancreatectomy
05/2021
1Lymph Node Excision (Lymph Node Dissection)
02/2020
1Gastrostomy
11/2019
1Surgical Flaps
09/2019
1Enema (Enemas)
09/2019
1Operative Surgical Procedures
09/2019
1Curettage
09/2019
1Proctectomy
08/2019
1Blood Transfusion (Blood Transfusions)
02/2016
1Catheters
09/2007